Use of simulation and modeling (“in silico- design”) tools is proving to be a powerful approach to help healthcare companies of all size reduce cost and increase quality in an increasingly challenging business climate. Discrete element modeling (DEM) in general, and Rocky DEM in particular, has emerged as a differentiated mechanistic modeling tool to advance process understanding of solid dosage and the small molecule drug manufacturing process. Most pharmaceutical materials involve particles. Rocky DEM accurately predicts the motion and interactions of discrete particles with each other and the surrounding boundaries, and can account for cohesion, particle deposition, liquid-solid interaction, particle breakage, etc.
Rocky DEM with/without coupling with computational fluid mechanics (CFD) is increasingly used to simulate pharmaceutical manufacturing and drug delivery systems. This webinar will provide an overview of Rocky and its applications to several pharmaceutical unit processes including tablet coating, powder mixing, blending, drying, inhaler design, tablet compaction, etc. The Rocky solution includes: the realistic representation of particle of any shape; the ability to run a large number of particles using multiprocessor GPUs (graphic processing units); and a flexible and fully customizable solver API (application programming interface). New possibilities in particle analysis are emerging, enabled by impressive gains in accuracy and reliability of modeling and simulation, combined with substantial scalability and computational speed. The webinar also will provide a perspective on predictive capabilities of simulation and applicability of the digital twin as a predictive tool soon.
Speaker: Ahmad H. Haidari, PhD, ESSS
- Application of Ansys simulation software in the healthcare industry.
- An overview of discrete element modeling (DEM) and how it is relevant to the pharma industry.
- Role of DEM and specifically Ansys Rocky as a mechanistic tool in drug manufacturing and drug delivery processes.