Innovation in healthcare is not just a question of business; often it is a matter of life and death. Medical and pharmaceutical companies must turn a profit, but they also have an ethical duty to improve lives. Healthcare organizations, therefore, face the dilemma of how to minimize cost and maximize efficiency. Simulation is an effective answer to this problem. In this issue of ANSYS Advantage, leading healthcare companies show how simulation has assisted them in reaching their bottom line goals while delivering safe and reliable products.