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CFD & Digital Twin of Clean Rooms: Contamination Control with ISO 14644

The ISO 14644-4:2022 claims that “the amount of air required for a particular cleanroom is not dependent on the volume of the room, but rather on the nature of the activities within the room and the design of the air distribution system” and suggests that “Computational fluid dynamics (CFD) is a suitable tool for [..] predicting the effectiveness of different cleanroom designs”.

We will review some limitations of the ACH evaluation and explain how AI and engineering simulation could nicely COMPLEMENT traditional methods. The suitability and validation of computational models by using the ASME VVUQ40 will be explained before unveiling the promise of clean rooms digital twin.

Date/Time:
December 11, 2025
11 AM EST / 5 PM CEST / 9:30 PM IST

Venue:
Virtual

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About this Event

Cleanroom design and contamination control are critical to ensuring product quality in highly regulated industries. This session explores how ISO 14644-4:2022 guides air distribution requirements, emphasizing that air needs depend on the type of activity and the design of the airflow system, rather than room volume alone.

We will highlight the limitations of traditional ACH-based evaluations and demonstrate how AI and advanced engineering simulations can complement conventional approaches to improve cleanroom performance. Attendees will also learn how computational models can be validated using the ASME V&V 40 framework, ensuring confidence in their predictions.

Finally, the event will showcase the promise of Cleanroom Digital Twins, a next-generation approach that enables continuous monitoring, optimization, and predictive control of contamination, bridging the gap between design and real-world operation.

What you will learn 

  • Understand ISO 14644-4:2022 guidelines and how cleanroom air requirements are determined by activity and airflow design.

  • Recognize the limitations of traditional ACH evaluations and when advanced methods are needed.

  • Learn how AI and engineering simulations can complement conventional approaches to optimize contamination control.

  • Discover the potential of Cleanroom Digital Twins for predictive monitoring, design validation, and real-time optimization.

Speakers

  • Thierry Marchal, Program Director for Healthcare Solutions, Synopsys
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