Advanced Modeling for Lyophilization to Reduce Time to Market and Cost
This presentation will explore the application of Ansys simulation tools to model and optimize the lyophilization process in pharmaceutical manufacturing. Lyophilization, or freeze-drying, is critical for enhancing the shelf life and stability of biologics, offering advantages such as reduced particulate contamination and preservation of heat-sensitive compounds. However, it poses significant engineering challenges, including ensuring product homogeneity and optimizing sublimation dynamics.
Through computational fluid dynamics (CFD), this presentation will demonstrate how simulation enables a deeper understanding of heat and mass transfer phenomena during lyophilization—insights often inaccessible through experimentation alone. Case studies will highlight equipment capability analysis and sublimation modeling to showcase the role of simulation in optimizing cycle parameters and system design. The session will emphasize how virtual prototyping supports faster development, improved product quality, and greater process efficiency in the freeze-drying of pharmaceuticals.
