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Towards Human Respiratory Digital Twin Using CFPD and PBPK Models

Dynamic modeling of how an inhaled therapeutic aerosol transports, deposits and translocates from human respiratory systems to systemic regions are essential for the realization of precise patient-specific pulmonary healthcare and paving the way toward a digital twin of respiratory systems.

November 18, 2020

11:00 AM (EST)

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Online

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This webinar will present a guide on how to use Computational Fluid-Particle Dynamics (CFPD) plus Physiologically Based Pharmacokinetic (PBPK) models to noninvasively predict the fate of inhaled and therapeutic aerosol in 3D patient-specific human respiratory systems. The step-by-step modeling procedure should help the audience set up the CFPD-PBPK/TK model accurately.

Starting from the fundamentals of CFPD-PBPK governing equations, we cover the problems of identification, pre-processing, solving and post-processing steps to perform a computational lung aerosol dynamics simulation, emphasizing (a) the importance of correct reconstruction and mesh generation of the pulmonary airways; (b) the significance of choosing the appropriate turbulence model to predict the laminar-to-turbulence pulmonary airflow regimes; and (c) the standard validation and verification procedures of submodels in the CFPD-PBPK modeling framework. We will highlight the missing biomechanisms and aerosol dynamics in the currently available CFPD-PBPK models that need to be considered to build the next-generation virtual human whole-lung models, including digital twins and personal digital avatars.

Moderator: Thierry Marchal, Ansys

Presenter: Yu Feng, Oklahoma State University

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