Ansys Zemax enabled Optotune to simulate and optimize advanced liquid lens systems for high-resolution medical imaging. Using physics-based modeling, engineers evaluated optical performance, minimized design iterations, and predicted real-world behavior before prototyping. The study demonstrates how simulation-driven design accelerated development while ensuring precision, reliability, and manufacturability. By integrating comprehensive analysis with rapid optimization, the team delivered imaging performance capable of supporting early disease detection. This case study highlights how advanced optical simulation reduces risk, shortens development timelines, and enables innovation in next-generation diagnostic technologies worldwide today across healthcare environments and demanding clinical performance requirements everywhere.