Simulation of Biomechanical and Chemical Transport in Human Tissue
This article presents the formulation of a novel method for applying the FEA code ANSYS to large-scale study of drug distribution and chemical transport in the human body. The methods described here can be used in combination with other simulation methodologies developed for studying mechanical responses of biological tissue. Various single-tissue or single-system models have been executed, as well as more traditional analytical treatments or physiologically based pharmacokinetic (PBPK) simulations, but to date, large-scale numerical models are not in use. In order to provide a complete picture of varying drug transport in different tissue on a macro scale, a more sophisticated modeling effort is necessary. This paper incorporates finite element theory and various clinical studies to propose an approach for expanding the scope and scale of delivery mechanisms, and convection-diffusion transport analyses.