Ninety-six percent of the top 50 healthcare companies in the world are using engineering simulation and computer-based models routinely. Leading medical device companies are realizing that their engineers should be using simulation regularly. The FDA and other regulatory authorities encourage the adoption of computer models and simulation — also known as the “in silico” approach — to accelerate the approval process, but many companies are still unsure of how best to adopt and deploy this technology. This monthly webinar series shares the knowledge and experience of Ansys experts and our partners to guide you in the strategic adoption of engineering simulation.

Upcoming Webinars

Successfully Digitalizing Drug Manufacturing

Thursday, February 25, 11 AM EST / 5 PM CET

The COVID crisis has revealed the importance of rapid and optimized equipment design and scale up for drug and vaccine manufacturing processing as well as the necessity to maintain an optimal productivity level throughout the equipment lifecycle. Most pharmaceutical and biopharma companies have now widely embraced engineering simulation to accelerate the design, scale up and optimization of these processes.

This webinar provides inspiring perspectives on the value of predictive models and advocates their increased adoption in the (bio)pharmaceutical industry. We will spotlight how computer models and simulations are used at various stages of development and manufacturing. Additionally, real-world chemical and biological product chain case studies will discuss how modeling contributes to the scientific advancement, strategic objectives and bottom line of typical technical operations.

  • Learn how engineering simulation helps improve the drug manufacturing process.
  • Discover quantified time and cost savings benefits for adopting modeling and simulation for drug manufacturing.
  • Explore what’s ahead to further optimize drug manufacturing.

Moderator: Thierry Marchal

Presenter: Luke Munholand


Patient-specific Bone Fracture Surgery Modeling

Thursday March 18, 11 AM EST / 5 PM CET

Minimally invasive techniques are increasingly used in traumatic surgery. Compared to open surgery, these methods present several advantages in terms of reduced morbidity, speed of recovery and quality of fracture reduction. However, due to the restricted area of exposure resulting from limited skin incision, direct observation of the bone fragments is not possible. For surgeons, thorough pre-operative planning and in-depth understanding of the biomechanical behaviours become necessary to define the optimal positioning of the surgical tools during the surgery to ensure efficient fracture reduction and stabilization.

This webinar spotlights how clinicians use Ansys Mechanical to create two patient-specific finite element models for evaluating the optimal fracture reduction and stabilization. Learn how they use Mechanical to model the geometry and behavior of fractured bone material and its interaction with surgical material.

The first model corresponds to fracture reduction, which consists of restoring the height of the bone structure with surgical balloon inflation. The second evaluates the stabilization technique including different lengths of screw and whether to perform PMMA cement injection or not.

Additionally, geometry extraction from 3D X-ray images of the patient, meshing, material properties allocation, surgical tool modelling and boundary conditions will be described.

Lastly, we will examine how clinicians use an interactive digital twin of the patient to analyze the impact of different reduction and stabilization solutions, in terms of mobility and constraints, for optimizing the surgical gestures per patient.

What attendees will learn

  • Explore patient specific simulation for trauma surgery.
  • Create a patient specific model of fractures by integrating the morphological and behavioral data specific to the patient.
  • Simulate trauma surgical gesture on a patient specific model.


  • Arnaud Germaneau, Associate Professor, Institut Pprime, UPR 3346 CNRS – Université de Poitiers, France
  • Kevin Aubert, PhD Student, Institut Pprime, UPR 3346 CNRS – Université de Poitiers, France

Moderator: Thierry Marchal, Ansys


Webinars on Demand

Virtuoso: A Virtual Platform for Precision Vascular Surgery

The clinical management of vascular disorders is challenging in terms of disease pathophysiology, risk factors and co-morbidities (among others) due to patient heterogeneity, all of which influence clinical decision making. To improve outcomes and patient satisfaction, the management of vascular diseases should be individualized. By exploiting advanced computational and 3D printing technologies we can generate more efficient, informative, and patient-specific workflows.

During this webinar, we will present a unique translational platform to enable precision vascular surgery (VIRTUOSO), combining state-of-the-art in vivo imaging, in silico (simulation) tools and in vitro testing in order to accurately quantify the hemodynamics of complex vascular pathologies, thereby informing individual treatment planning. To demonstrate the potential of this technology, which is entirely generalizable to other (cardio) vascular pathologies, we will use a complex and highly patient specific condition, chronic Type-B aortic dissection, as an example.

We will demonstrate how we use clinical data to build advanced patient-specific computational models of the pathology as well as 3D-printed phantoms for experimental testing and validation on a unique and personalizable flow circuit, thus overcoming major obstacles for clinical and industrial translation.

What you will learn

  • Learn how to go from a patient-specific CT scan to hemodynamics results
  • Compare in vitro and in silico measurements and results
  • See how to guide clinical decision from simulation results

Presenter: Vanessa Diaz, Professor of Healthcare Engineering, University College London

Moderator: Thierry Marchal, Ansys

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Towards Human Respiratory Digital Twin Using CFPD and PBPK Models

Dynamic modeling of how an inhaled therapeutic aerosol transports, deposits and translocates from human respiratory systems to systemic regions are essential for the realization of precise patient-specific pulmonary healthcare and paving the way toward a digital twin of respiratory systems.

This webinar will present a guide on how to use Computational Fluid-Particle Dynamics (CFPD) plus Physiologically Based Pharmacokinetic (PBPK) models to noninvasively predict the fate of inhaled and therapeutic aerosol in 3D patient-specific human respiratory systems. The step-by-step modeling procedure should help the audience set up the CFPD-PBPK/TK model accurately.

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Enabling the Digital Transformation of Healthcare Using Ansys Granta and Minerva

Healthcare companies are struggling with compliance and traceability of materials data in their product development processes. They also need a robust and compliant method for communicating the results of their simulation activities to regulators in an era when digitalization of their products is critical to success.

This webinar spotlights Ansys Granta’s capabilities for importing and analyzing materials data, used to characterize and qualify the materials arriving from suppliers and leveraged by simulation engineers to ensure performance. Utilizing Ansys Minerva to ensure the traceability of the materials data from Granta to WB simulation to regulatory agency reporting will also be discussed.

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How Particles Issues Can Ruin Your Pharmaceutical Process — and the Modeling Solution to Avoid It

In the pharmaceutical industry, granular materials are handled by equipment that perform processes such as powder mixing and blending, powder compaction, granulation and tablet coating. Pharmaceutical equipment design is very important to the control of the tablet mixing to avoid defects such as tablet erosion, over-coating, and high coating variability between the tablets.

Attend this webinar and learn how DEM and CFD simulations can be used to predict tasks like tablet mixing in a coating operation. Find out how to improve and develop high-efficiency pharmaceutical equipment design.

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Modeling a Dielectrophoresis-based Application to Personalize Cancer Treatment and Increase Recovery Rates

Modern bio-medicine practitioners are showing increasing interest in dielectrophoresis (DEP) because of the recent progress in the development of micro-electrodes. DEP gives you control of the trajectories of bio-particles (tumor cells, white blood cells, bio-markers, etc.), resulting in efficient separation and/or selective trapping with low particle damage.


View this on-demand webinar and learn how using ANSYS simulation as a virtual prototyping tool can shorten the path to commercialization of this technology and make it more robust and repeatable. We will demonstrate how to explore and optimize electrode design and operating conditions to adapt them to the specific properties of bio-particles.

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Preventing Surgical Site Infections in Modern Operating Rooms

“The solution to pollution is dilution” has long been the standard philosophy when it comes to cleanroom applications of HVAC equipment. However, preventing surgical site infections (SSIs) in modern operating rooms is often associated with ensuring laminar downwash of air over the patient on the operating table. While some research indicates that laminar flow is indeed the answer, other works contraindicate this finding, concluding that laminar airflows are no more or less effective than dilution methods in preventing SSIs. Using ANSYS CFD, Nortek Air Solutions has been able to demonstrate that their Cleansuite products meet both laminar downwash and dilution design requirements, ensuring that operating rooms fitted with Nortek cleanroom products are as safe as possible for patients.

View this webinar and learn how computational fluid dynamics (CFD) can help to optimize airflow in the operating room and prevent surgical site infections (SSIs). Concrete examples as well as the benefits of this innovative modeling approach will be discussed.

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In-silico Modeling of the Patient-specific Heart

The predictive modeling of cardiac mechanics to accurately reproduce the heart’s functionality and response to external disturbances remains a challenging task. The need to assess multiple physical domains — structural mechanics, fluid dynamics and electrophysiology — places high demands on numerical solution strategies.

We will present a high-resolution, 3-D, nonlinear finite element model of patient-specific heart geometries and function. The model includes an active material law prescribing the ventricular contraction along a generic muscle fiber orientation and a passive component that captures the highly anisotropic nonlinear behavior of the myocardium.

By coupling the structural model with the ventricular blood compartments, which act as zero-dimensional fluid representations of the cardiovascular system, we can model venous return by assuring conservation of volume within the closed loop circulatory system. The resulting monolithic, multifield system of equations, provides a physiologically meaningful solution of heart contraction mechanics for in silico modeling of medical device and novel disease treatment.

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Computational-based MRI Thermal Injury Risk Assessment for Patients implanted with Passive Spinal Devices

Using computational modeling and simulation (CM&S) to generate evidence that a medical device meets regulatory standards is evolving quite rapidly. Regulatory agencies such as the FDA are increasingly accepting simulation data as part of the approval process. In this webinar, we will address the use of CM&S to assess the safety of patients with implanted passive devices who must undergo MRI scanning. The goal is to answer the question, “Will radio-frequency field interaction with the implanted device induce unsafe high temperatures in the surrounding tissues?”

View this webinar to learn more about the role of CM&S as a tool in generating evidence for MR device safety. The speaker will also cover important topics such as worst-case selection methodology and computational model verification, validation and uncertainty quantification.

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Closing the Loop on Medical Device Systems Simulation: An Insulin Delivery System

Computational modeling is recognized by both industry and regulatory agencies as an alternative to physical testing, but it has historically been used in silos with minimal collaboration between various design disciplines and engineering departments. To address the needs of today’s product development teams, ANSYS has developed a multi-domain, system simulation and digital prototyping platform that enables multi-specialty teams with diverse engineering backgrounds to work in unison to achieve a deep understanding of integrated product behavior.

Attend this webinar to learn about a systems simulation solution of a wearable insulin pump that illustrates the complexities of developing these multi-disciplinary systems. The model includes evaluation of various physical components, control algorithms, display interfaces and power electronics. In addition to the presentation, a live demo will show how various components can be combined to model the drug delivery sub-system using a hardware-in-the-loop approach.

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Changing Development And Manufacturing Paradigms in Biopharmaceutical Operations

This webinar provides a compelling overview of how predictive models are used at various stages of development and manufacturing in the biopharmaceutical industry. Case studies covering a wide range of the biologic product chain from drug substance to drug product and devices are presented, to show how modeling contributes to the scientific advancement, strategic objectives, and bottom line of our technical operations at Biogen. While our main focus is on mainstream applications of CFD modeling in the biopharmaceutical industry, non-traditional uses of CFD and other first-principles modeling techniques will also be presented here. Through this presentation, we intend to provide inspiring perspectives on the value of predictive models and advocate their increased adoption in the Biopharmaceutical industry.

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New Orthopedic Shoulder Implants: Optimized through Patient Specific Multiphysics Modeling

For more than 20 years, the orthopedic sector has widely adopted engineering simulation and finite element analysis to accelerate the development of new implants. Today, most hip prostheses, knee joints and spinal implants are optimized through computer modeling. During the last few years leading orthopedic companies have developed an in silico testing approach, which enables them to test new prototypes on a relatively large population of virtual patients.

Attend this webinar to learn how ANSYS simulation solutions can give you a more detailed understanding of all articulations including the shoulder, elbow, wrist and ankle. For patient-specific implants to become standard, including synovial fluid and electromagnetic interaction modeling are the obvious next steps. Learn about a workflow that takes you from patient to simulation, while including fluid–structure interaction behavior in your shoulder model.

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How the Platform Can Help Define Good Simulation Practices

Recent reports by the EU Council and U.S. Congress encourage a number of innovative approaches to streamline the regulatory approval process for approving medical devices, including the large-scale adoption of computer-based models. The extensive use of simulation in clinical research will lead to the definition of Good Simulation Practice (GSP) standard guidelines for computer modeling and testing as Good Clinical Practices (GCP) are used in traditional clinical trials.

Attend this webinar to learn how the web-based platform,, will provide healthcare companies with an easy-to-use tool to perform computational testing on their devices during the development and validation process.

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Leveraging Engineering Simulation in the Development of Vaccine Delivery Devices

Intranasal delivery can provide better protection than traditional injected vaccines for diseases such as influenza due to mucosal and cross-protection. But current intranasal delivery technology uses expensive and difficult-to-manufacture vaccines inefficiently. Creare has recently developed two novel vaccine delivery devices: a dry powder inhaler (DPI), which effectively delivers the vaccine dose to targeted regions of the nasal tract; and an ultra-compact InVaxTM intranasal nebulizer for liquid vaccines, which is an optimal platform for large-scale influenza vaccination.

Attend this webinar to learn how Creare used ANSYS Fluent for aerodynamic design and nasal deposition modeling in support of the DPI device development. Discover how analyses performed with ANSYS Mechanical were used to design the piezoelectric actuator, a key component in the aerosol generation process for the InVax device.

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Vertical Medical Applications: Bringing Simulation to Clinicians

For years clinicians have progressively discovered the benefits that engineering simulation can bring to medicine. Still, fidelity of simulation for a large variety of patients, computational time and ease of use of existing general purpose tools have remained strong entry barriers to simulations for doctors. Now, building on their long medical and engineering experience and taking advantage of new ANSYS 17.0 capabilities to further improve their inventions, medical entrepreneurs are increasingly customizing ANSYS solutions to their clinical needs.

Attend this webinar to learn how two entrepreneurial clinical groups have adapted ANSYS software for new medical treatments. Discover how BRACESIM, developed by Rodin 4d, assists orthotists in customizing braces to treat scoliosis, decreasing the number of physical iterations needed to get the right brace, while reducing brace weight and increasing patient satisfaction. And find out how WOST, created by Sim & Cure, provides crucial assistance to neurosurgeons treating cerebral aneurysms by performing patient-specific stent development in less than 15 seconds.

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Quality by Design: Using Simulation for Biotech and Pharmaceutical Mixing Tank Scale-Up: No Need of CAE Experts Anymore

Mixing tank design scale-up has traditionally required a large number of CAE experts. While engineering simulation has strongly reduced development costs and time to market, using CAE experts made this task increasingly cost-prohibitive, until now. Join us for this webinar to discover how the ANSYS India team, working with some pharma and biotech leaders, developed a simplified, customized interface for ANSYS Fluent that enables non-expert users to set up advanced mixing tank modeling. Learn how this innovative mixing tank template allows new users to gain simulation experience, while freeing up CAE experts for more advanced tasks.

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Quality by Design: The Strategic Role of Simulation in this Essential Pharmaceutical Initiative

Quality by Design (QbD) is a concept encouraged by the FDA that integrates quality into a product through understanding of both the product and the process by which it was manufactured. This webinar will provide an introduction to the application of CFD tools in the biopharmaceutical industry and will continue with two case studies. Both case studies will focus on designing production-scale bioreactors using CFD. The first will summarize a DOE-based design of bioreactor to optimize gas sparging, and the second will describe a methodology to engineer and design a production-scale bioreactor that reduces the risk of scaling-up a microcarrier-based mammalian cell culture process.

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AirPROM: Airway Disease Predicting Outcomes through Patient Specific Computational Modelling

AirPROM (Airway Disease Predicting Outcomes through Patient Specific Computational Modeling) is a five year European project; it aims to produce computer and physical models of the whole airway system for people with asthma and chronic obstructive pulmonary disease. Using a model of a patient’s own airway system and simulating its functionality through software could help to improve diagnoses, treatments and outcomes for people suffering from these conditions.

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How ANSYS SpaceClaim Will Help You Streamline In Silico Testing and Computer Aided Surgery

Customizing surgical treatments and medical devices by incorporating patient-specific geometries in simulations opens the door to better, more successful healthcare. Patient-specific geometries typically come from medical scans — MRI, PET, CT — and they often require preprocessing for accurate simulations. In this webinar, we will discuss how ANSYS SpaceClaim provides the medical community with new techniques to make editing of patient-specific geometries faster and easier, leading to better treatment planning and more successful outcomes.

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Implementing a Microstructure-enhanced Material Model using ANSYS USERMAT for the Prediction of Bone Failure

Continuum FE models of bones and bone-implant configurations have become a standard tool to estimate bone strength. These models are usually based on clinical CT scans. In virtually all of these models, material properties assigned to the bone elements are chosen as isotropic with a stiffness based only on the density distribution. It has been shown, however, that trabecular bone can be highly anisotropic and it shows elastic plastic damage mechanical behaviour with softening.

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